大规格圆棒用滚动导卫开度调节系统的改进

针对大规格圆棒生产用滚动导卫在轧制过程中导辊开度不能保持在设定值，影响产品质量及生产顺行的问题，通过对该类型导卫开度调节装置的工作原理及结构分析，明确了结构设计及选用材质与使用工况不匹配是问题产生的主要原因。为此，对调节装置进行了设计优化，改进后的导卫在线时间显著提高。     

采场顶板关键层"横U-Y"型周期破断特征的试验研究

针对部分坚硬顶板矿井采动导水裂缝带处于8~15倍采高的高位关键层,"横O-X"破断运动引发工作面动载矿压甚至压架、临采空侧回风平巷超前100~200 m底鼓大变形等动力灾害的问题,采用自制的大尺度三维物理模拟实验平台,研究高位关键层的破断运动特征。结果表明:关键层发生横向破断时,首先,关键层板正面两侧长边和反面中部长轴方向同时形成破断裂隙;其次,关键层板正面两侧短边形成弧形裂隙,而反面沿中轴线端点同步形成八字形破断裂隙;再次,在板正面形成"O"形裂隙的同时反面形成"X"形裂隙,正面形成"U"形裂隙的同时反面形成"Y"形裂隙;最后,正反面裂缝贯通形成"横O-X"型初次破断和"横U-Y"型周期破断,在工作面上方形成"弧形三角板"和巷道上方形成"梯形板"的破断块体结构。统计发现,"横O-X"型初次破断步距与"横U-Y"型周期破断步距长度基本一致;横向破断形成的"弧形三角板"块体角度为75°~78°,与腰线和弧形切线形成的夹角72°~82°基本相等,近似于一个等角的"弧形三角板"。砌块模型试验结果表明,"弧形三角板"块体大幅回转过程中,因其顶点易与"梯形板"结构发生回转变形失稳而出现脱离现象,导致"弧形三角板"滑落失稳从而会引发工作面强矿压。研究成果为大采高开采工作面强矿压灾害防治提供试验基础。     

Grain boundary engineering that induces ultrahigh permittivity and decreased dielectric loss in CdCu3Ti4O12 ceramics

Dielectric materials with ultrahigh permittivity are attracting attention due to the increasing demand for these types of materials for microelectronics and energy storage applications. In this work, we successfully synthesized Zn-doped CdCu₃Ti₄O₁₂ (CdCTO) ceramics with low dielectric loss and large permittivity via an ordinary mixed-oxide technique. Remarkably, at a Zn doping level of 0.10, a CdCu_2.9Zn_0.1Ti₄O₁₂ ceramic exhibited both decreased dielectric loss tangent of ~0.058 and large dielectric permittivity > 4.0 × 10⁴, as well as a good frequency stability over a wide frequency range from 40 Hz to 10⁶ Hz. The high dielectric performance was attributed to the enhanced grain boundary resistance and internal barrier layer capacitor (IBLC) effect due to the fine and uniform grains that formed upon Zn doping. The findings reported in this work provide valuable insights into how to simultaneously realize a low dielectric loss and high permittivity in CdCTO and other related dielectric ceramics.     

化工大型机组的管理保养技术

化工机组设备的维护、保养和管理工作的在企业之中是非常重要的,只有提升企业管理、维护、保养机组的工作水平才能够让企业跟上时代发展的脚步。对化工机组设备维护管理的意义、维护保养的技术及其存在的问题和难点逐一进行介绍。     

生产信息管理系统关键技术研究

根据公司生产控制系统现状和发展需要,分析和探讨建立公司生产信息管理系统(PIMS)的软硬件基本构成和主要方法,并对以隔离网关、实时数据库、能源计量管理等为基础的生产信息管理系统关键技术进行研究和测试。     

地下水封石油储库硬岩大断面控制爆破

大型地下水封石油储库作为原油战略储备的一种重要手段,在世界范围内被普遍采用。地下水封储库不同于其他岩石地下工程,其跨度大、边墙高、开挖断面特大,同时要求爆破振动低、围岩损伤小、稳定性高,对开挖爆破有着更为严格的要求。本文以华南某地下水封石油储库硬岩特大断面爆破开挖为例,基于钻爆开挖的特殊要求,提出"大洞小打、分部开挖"的施工原则,划大断面为小断面,分层分次爆破。采用复式楔形掏槽、毫秒延迟起爆、周边孔光面爆破等技术,综合选取孔径、孔深、孔距、最小抵抗线、炸药单耗及炮孔数目等参数,精心设计炮孔布置、装药及起爆顺序,给出爆破方案。实践表明,爆破振动、炮孔利用率、壁面成型、开挖进尺等均达到了预期,较好地满足了洞库开挖要求,特大断面硬岩爆破设计能够取得良好的爆破效果,可为类似工程提供借鉴与参考。     

Study on inhomogeneous cooling behavior of extruded profile with unequal and large thicknesses during quenching using thermo-mechanical coupling model

The interfacial heat transfer coefficient between hot profile surface and cooling water was determined by using inverse heat conduction model combined with end quenching experiment. Then, a Deform-3D thermo-mechanical coupling model for simulating the on-line water quenching of extruded profile with unequal and large thicknesses was developed. The temperature field, residual stress field and distortion of profile during quenching were investigated systematically. The results show that heat transfer coefficient increases as water flow rate increases. The peak heat transfer coefficient with higher water flow rates appears at lower interface temperatures. The temperature distribution across the cross-section of profile during quenching is severe nonuniform and the maximum temperature difference is 300 °C at quenching time of 3.49 s. The temperature difference through the thickness of different parts of profile first increases sharply to a maximum value, and then gradually decreases. The temperature gradient increases obviously with the increase of thickness of parts. After quenching, there exist large residual stresses on the inner side of joints of profile and the two ends of part with thickness of 10 mm. The profile presents a twisting-type distortion across the cross-section under non-uniform cooling and the maximum twisting angle during quenching is 2.78°.     

大宗粉煤灰的综合利用及提质方案

对于大宗粉煤灰原灰进行分选加球磨机粉磨，同时添加合适的激发剂进行提质，可以生产出不同细度和活性的粉煤灰产品，提升粉煤灰在水泥及商品砼中的用量。介绍了某发电公司的粉煤灰处置现状，在此基础上，对商品砼的粉煤灰性能要求进行了大量市场调研，针对性地给出了该公司粉煤灰的提质方案，最后进行了提质粉煤灰的应用市场和产品竞争力分析。     

Self‐Assembled Aptamer‐Nanomedicine for Targeted Chemotherapy and Gene Therapy

Chemotherapy is the mainstream treatment of anaplastic large cell lymphoma (ALCL). However, chemotherapy can cause severe adverse effects in patients because it is not ALCL‐specific. In this study, a multifunctional aptamer‐nanomedicine (Apt‐NMed) achieving targeted chemotherapy and gene therapy of ALCL is developed. Apt‐NMed is formulated by self‐assembly of synthetic oligonucleotides containing CD30‐specific aptamer and anaplastic lymphoma kinase (ALK)‐specific siRNA followed by self‐loading of the chemotherapeutic drug doxorubicin (DOX). Apt‐NMed exhibits a well‐defined nanostructure (diameter 59 mm) and stability in human serum. Under aptamer guidance, Apt‐NMed specifically binds and internalizes targeted ALCL cells. Intracellular delivery of Apt‐NMed triggers rapid DOX release for targeted ALCL chemotherapy and intracellular delivery of the ALK‐specific siRNA induced ALK oncogene silencing, resulting in combined therapeutic effects. Animal model studies reveal that upon systemic administration, Apt‐NMed specifically targets and selectively accumulates in ALCL tumor site, but does not react with off‐target tumors in the same xenograft mouse. Importantly, Apt‐NMed not only induces significantly higher inhibition in ALCL tumor growth, but also causes fewer or no side effects in treated mice compared to free DOX. Moreover, Apt‐NMed treatment markedly improves the survival rate of treated mice, opening a new avenue for precision treatment of ALCL.     

MySQL数据库的数据隐私及安全机制研究

随着现代化信息技术发展与普及,互联网计算机系统已成为人们工作生活不可或缺一部分。MySQL数据库作为一种数据库管理系统,数据传输速度快,体积小,能够开放源代码,具备一定可靠性和适应性,是当前网络信息系统后台数据库优先原选择对象。因此,MySQL数据库安全性能尤为重要,是确保网络信息系统安全、顺利运行根本保障。